Effects of Low Power Laser Irradiation on Intracellular Calcium and Histamine Release
LLLT/Laser Therapy hass been shown to have positive bio-stimulation effects on living organisms both in vitro and in vivo. Enhanced histamine release in RBL-2H3 mast cells in vitro takes place after laser irradiation. Because of the multi-functions of histamine, such as vasodilation, increased vessel permeability, increased endothelial cell proliferation and nervous stimulation (13-17), and of the fact that mast cells exist in skin tissue in large extents and accumulate at the site of the wound, histamine release from mast cells is probably one of the reasons for the effect of laser irradiation on promoting wound healing.
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