Interesting Studies

Treatment with LLLT over one year increased scalp hair as determined by scalp hair counts, patient self-assessment, investigator assessment, and global photographic assessment, when compared with placebo. Long-term treatment was generally well tolerated, and the results of these studies demonstrate that LLLT leads to durable improvements in hair growth in men with MPHL and women with FPHL and slows the further progression of hair loss that occurs without treatment.

Six studies from WAY BACK that showed that LLLT was growing hair. Why did so many people ignore these? [I know the answer! It was the flood of inferior devices that didn't get results!]

A breakdown of one of the findings of how LLLT / Laser Therapy fights hair loss! From the study: Increased RNA and protein synthesis was demonstrated after 5J/cm2. Pastore et al found increased activity ofcytochrome c oxidase and an increase in polarograph-ically measured oxygen uptake after 2 J/cm2of HeNe.A major stimulation in the proton pumping activity,about 55% increase of H+/e- ratio was found in illu-minated mitochondria. Yu et al used a 660 nm laser ata power density of 10 mW/cm2and showed increasedoxygen consumption (0.6 J/cm2and 1.2 J/cm2),increased phosphate potential, and energy charge (1.8J/cm2and 2.4 J/cm2) and enhanced activities ofNADH: ubiquinone oxidoreductase, ubiquinol: ferricy-tochrome C oxidoreductase and ferrocytochrome C:oxygen oxidoreductase (0.6 J/cm2, 1.2 J/cm2, 2.4 J/cm2and 4.8 J/cm2).

Laser irradiation on only the right side in bilaterally inflicted cutaneous wounds enhanced recovery in both sides compared to the nonirradiated control group. The bilateral retrograde degeneration of the motor neurons of the spinal cord expected after the bilateral crush injury of the peripheral nerves was greatly reduced in the laser treated group.

Light of a number of different wavelengths, specifically 660, 820, 870nm, at an energy density of 2.4J/cm2, has been shown to stimulate the ability of macrophages in vitro to release growth factors, which stimulate fibroblast proliferation. At 660nm the stimulatory effect of LLLT is dose dependent for exposure to energy densities of 2.4 - 7.2J/cm2, the upper end of the range being most effective and with 9.6J/cm2 proving to be less effective than 7.2J/cm2.

Laser Therapy massively helps would healing: The results show that the correct energy density or fluence (J/cm(2)) and number of exposures can stimulate cellular responses of wounded fibroblasts and promote cell migration and cell proliferation by stimulating mitochondrial activity and maintaining viability without causing additional stress or damage to the wounded cells. Results indicate that the cumulative effect of lower doses (2.5 or 5 J/cm(2)) determines the stimulatory effect, while multiple exposures at higher doses (16 J/cm(2)) result in an inhibitory effect with more damage.

This study was brought to my attention by S Foote from www.​Hairloss​Talk​.com. He has a very interesting theory that lymphedema of the MPB area caused by androgens plays a role in hair loss, and this may be one of the mechanisms behind success.

LLLT/Laser Therapy hass been shown to have positive bio-stimulation effects on living organisms both in vitro and in vivo. Enhanced histamine release in RBL-2H3 mast cells in vitro takes place after laser irradiation. Because of the multi-functions of histamine, such as vasodilation, increased vessel permeability, increased endothelial cell proliferation and nervous stimulation (13-17), and of the fact that mast cells exist in skin tissue in large extents and accumulate at the site of the wound, histamine release from mast cells is probably one of the reasons for the effect of laser irradiation on promoting wound healing.

"They induce collagen remodeling at the ultrastructural level and increase collagen production". This is IMPORTANT for what we are trying to accomplish!

I find this very interesting because of the increasing number of theories that tie MPB and acne together.